Flavin Range of Products

Description:

Flavin:Isotonic Riboflavin Ophthalmic solution

Flavin is a sterile, preservative-free ophthalmic solution containing Riboflavin 0.1% and Dextran in saline buffer for external ocular usage.

Flavin TE: Transepithelial Riboflavin Ophthalmic Solution

Flavin TE is a sterile, preservative-free ophthalmic solution containing Riboflavin 0.25% and dextran in Saline with EDTA & Tromethamine.

Flavin HY: Hypotonic Riboflavin Ophthalmic Solution without dextran

Flavin HY is a sterile, preservative-free ophthalmic solution containing Riboflavin 0.25% in saline.

Flavin H: Riboflavin Ophthalmic solution with Hypromellose

Flavin H is sterile, preservative-free ophthalmic solution of Riboflavin 0.1% in saline with Hypromellose

Indications:

Flavin, Flavin TE & Flavin H

They are used as a photo sensitizing agent in Corneal Collagen cross linking as a treatment for patients with Keratoconus and Corneal Ectasia in different corneal conditions.

Flavin HY:

Flavin HY is used to swell the cornea if corneal thickness is not sufficient to perform Corneal Collagen cross linking as well as photosensitizing agent in Corneal Collagen cross linking.

Collagen cross linking with Riboflavin - the Mechanism :

  • Riboflavin (vitamin B2) has 2 important functions; it absorbs UV irradiation and acts as a photosensitizer for the generation of reactive oxygen species (singlet oxygen).
  • In combination with UV-A light, Riboflavin forms radicals that cause the cross linking.
  • When Riboflavin penetrates the stroma sufficiently, it shields the deeper tissues such as the Lens and Retina.
  • UV-A light of 370 nm wavelength (Riboflavin’s absorption maximum) and 3mW/cm2 is generally used.
  • The 370 nm wavelength allows approximately 95% of UV-A light to be absorbed into the Cornea; thus, there is no risk for damage to the Lens and Retina.

Collagen cross linking with Riboflavin - the Technique :

  • As a photosensitizer, 0.1% Riboflavin solution is applied to the Cornea 20 minutes before the irradiation to allow sufficient saturation of the Stroma.
  • Next, an 8.0 mm diameter of central Cornea is irradiated with UV-A light with a wavelength of 370 nm and an irradiance of 3 mW/cm2.
  • During the 30 minutes of irradiation, drops of Riboflavin solution is applied to the cornea every 4 to 5 minutes to sustain the necessary concentration of the Riboflavin and prevent desiccation of the Cornea.
  • The Corneal cross-linking treatment with Riboflavin for Keratoconus increases the amount of Collagen cross-linking in the Cornea in order to strengthen the Cornea. The newly strengthened Cornea protects against the bulging out and becoming steep and irregular, consequence of advanced Keratoconus.

Advantages of Cross Linking Treatment with Flavin, Flavin TE & Flavin H:

  • Causes an increase in Corneal stiffness of the anterior 200-250 um.
  • Cross- linking effects are directed to the anterior Cornea because of Flavin’s high UV-A absorption capacity. Thus Corneal Endothelium, Lens and Retina will be protected.
  • Dextran in FLAVIN helps
    • Maintains the Osmolarity
    • Avoids corneal soaking and swelling during the treatment
  • Halts the progress and causes some regression.
  • No injection, no stitches & no incisions as in Keratoplasty.
  • Quick & Easy treatment with low costs.

Advantages of Cross Linking Treatment with Flavin HY:

  • To swell the cornea upto the thickness of minimum 400 ┬Ám.
  • To better maintain consistent corneal thickness during UV administration.
  • This variant of Riboflavin broadens the spectrum of Riboflavin treatment to thin corneas that would otherwise not be eligible for the treatment.

Technical Specifications:

Flavin Isotonic Riboflavin Ophthalmic Solution (0.1%)
COMPOSITION Each ml contains
Riboflavin Sodium Phosphate BP
(Equivalent to base Riboflavin).........................0.1% w/v
Dextran P500....................................................20.0% w/v
Phoshpate Buffar Saline...................................q. s.
Flavin HY Hypotonic Riboflavin Ophthalmic Solution (0.25%) without Dextran
COMPOSITION Each ml contains
Riboflavin Sodium Phosphate BP
(Equivalent to base Riboflavin)........................0.25% w/v
Phoshpate Buffar Saline...................................q. s.
Flavin TE Transepithelial Riboflavin Ophthalmic Solution (0.25%)
COMPOSITION Each ml contains
Riboflavin Sodium Phosphate BP
(Equivalent to base Riboflavin)........................0.25% w/v
Dextran P500 ...................................................15% w/v
Phoshpate Buffar Saline....................................q. s.
EDTA, Tromethamine (TRIS)
Flavin H Riboflavin Ophthalmic Solution (0.1%) with Hypromellose
COMPOSITION Each ml contains
Riboflavin Sodium Phosphate BP
(Equivalent to base Riboflavin).........................0.1% w/v
Phoshpate Buffar Saline....................................q. s.
Hypromellose

Supply:

  • Flavin range of products are supplied individually in ready to single use sterile Prefilled Syringe of 1.0 ml with sterile single use Cannula.
  • Flavin range of products can be supplied with filled volume of 3.0 ml for special orders.